Rana SANYAL
Position: 
Principal Investigator
Educational Background: 

1994 – 2001     Ph.D. in Chemistry,

                       Boston University, Boston, MA.

1990 – 1994     B.S. in Chemical Engineering,

                       Bogazici University, Istanbul, Turkey.

Research: 

           Targeted drug delivery agents for cancer chemotherapy  

           Novel materials for biomedical applications

 

Awards:

Outstanding Teaching Fellow Award, College of Arts and Sciences, Boston University, 1999.

L'Oréal Women in Science Fellowship, 2006. 

Novartis `Pharmaceutical and Medicinal Chemistry Drug Design and Development` Research Award, 2008.

Turkish National Academy of Sciences, Young Investigator Award, 2011.

Boğaziçi University, Outstanding Researcher Award, 2012.

Publications: 

·        Halouane, F.; Oz, Y.; Meziane, D.; Barras, A.; Juraszek, J.; Singh, S. K.; Kurungot, S.; Shaw, P. K.; Sanyal, R.; Boukherroub, R.; Sanyal, A.; Szunerits, S. “Magnetic reduced graphene oxide loaded hydrogels: Highly versatile and efficient adsorbents for dyes and selective Cr(VI) ions removal” Journal of Colloid and Interface Science (2017), 507, 360-369.

·        Cengiz, N.; Gevrek, T. N.; Sanyal, R.; Sanyal, A. “Orthogonal thiol-​ene 'click' reactions: a powerful combination for fabrication and functionalization of patterned hydrogels” Chemical Communications (Cambridge, United Kingdom) (2017), 53(63), 8894-8897. 

·        Gok, O.; Erturk, P.; Sumer Bolu, B.; Gevrek, T. N.; Sanyal, R.; Sanyal, A. “Dendrons and Multiarm Polymers with Thiol-​Exchangeable Cores: A Reversible Conjugation Platform for Delivery” Biomacromolecules (2017), 18(8), 2463-2477.

·        Aydin, D., Arslan, M., Sanyal, A. and Sanyal, R. ‘Hooked on Cryogels: A Carbamate Linker Based Depot for Slow Drug Release’ Bioconjugate Chemistry  (2017)28, 1443–1451.

·        Karacivi, M.; Bolu, B. S., and Sanyal, R. Targeting to the Bone: Alendronate-Directed Combretastatin A-4 Bearing Antiangiogenic Polymer–Drug Conjugates Molecular Pharmaceutics (2017), 14, 1373-1383.

·        Aktan, B.; Chambre, L.; Sanyal, R.; Sanyal, A. “"Clickable" Nanogels via Thermally Driven Self-​Assembly of Polymers: Facile Access to Targeted Imaging Platforms using Thiol-​Maleimide Conjugation” Biomacromolecules (2017), 18, 490-497.

·        Munkhbat, O.; Gok, O.; Sanyal, R.; Sanyal, A. “Multiarm star polymers with a thermally cleavable core: A "grafting-​from" approach paves the way” Journal of Polymer Science, Part A: Polymer Chemistry (2017) 55, 885-893.

·        Teodorescu, F.; Oz, Y.; Queniat, G.; Abderrahmani, A.; Foulon, C.; Lecoeur, M.; Sanyal, R.; Sanyal, A.; Boukherroub, Rabah; Szunerits, S. Photothermally triggered on-​demand insulin release from reduced graphene oxide modified hydrogels Journal of Controlled Release (2017) 246, 164-173. 

·        Sumer Bolu, B.; Manavoglu Gecici, E.;  Sanyal, R. “Combretastatin A-4 Conjugated Anti-Angiogenic Micellar Drug Delivery Systems Using Dendron-Polymer Conjugates” Molecular Pharmaceutics (2016) 13, 1482-1490.

·        Yavuz, B., Bozdağ Pehlivan, S., Sümer Bolu, B., Nomak Sanyal, R., Vural, İ. and Ünlü, N. Dexamethasone – PAMAM dendrimer conjugates for retinal delivery: preparation, characterization and in vivo evaluation. J Pharm Pharmacol (2016), 68, 1010–1020.

·        Kaga, S.; Arslan, M.; Sanyal, R.; Sanyal, A. “Dendrimers and dendrons as versatile building blocks for the fabrication of functional hydrogels” Molecules (2016), 21(4), 497/1-497/25.  

·        Altinbasak, I.; Sanyal, R.; Sanyal, A. “Best of both worlds: Diels-​Alder chemistry towards fabrication of redox-​responsive degradable hydrogels for protein release” RSC Advances (2016), 6(78), 74757-74764. 

·        Oz, Y.; Arslan, M.; Gevrek, T. N.; Sanyal, R.; Sanyal, A. “Modular Fabrication of Polymer Brush Coated Magnetic Nanoparticles: Engineering the Interface for Targeted Cellular Imaging” ACS Applied Materials & Interfaces (2016), 8(30), 19813-19826. 

·        Kalaoglu-Altan, O. I.; Verbraeken, B.; Lava, K.; Gevrek, T. N.; Sanyal, R.; Dargaville, T.; De Clerck, K.; Hoogenboom, R.; Sanyal, A. “Multireactive Poly(2-​oxazoline) Nanofibers through Electrospinning with Crosslinking on the Fly” ACS Macro Letters (2016), 5(6), 676-681.

·        Kaga, S.; Gevrek, T. N.; Sanyal, A.; Sanyal, R. “Synthesis and functionalization of dendron-​polymer conjugate based hydrogels via sequential thiol-​ene "click" reactions” Journal of Polymer Science, Part A: Polymer Chemistry (2016), 54(7), 926-934. 

·        Kaga, S.; Yapar, S.; Manavoglu Gecici, E.; Sanyal, R. Photopatternable "Clickable" Hydrogels: "Orthogonal" Control over Fabrication and Functionalization Macromolecules (Washington, DC, United States) (2015), 48(15), 5106-5115. 

·        Gok, O.; Kosif, I.; Dispinar, T.; Gevrek, T. N.; Sanyal, R.; Sanyal, A. Design and synthesis of water-​soluble multifunctionalizable thiol-​reactive polymeric supports for cellular targeting  Bioconjugate Chemistry (2015), 26(8), 1550-1560.

·        Kalaoglu-Altan, O. I.; Sanyal, R.; Sanyal, A. "Clickable" Polymeric Nanofibers through Hydrophilic-​Hydrophobic Balance: Fabrication of Robust Biomolecular Immobilization Platforms Biomacromolecules (2015), 16(5), 1590-1597. 

·        Kalaoglu-Altan, O. I.; Sanyal, R.; Sanyal, A. Reactive and 'clickable' electrospun polymeric nanofibers Polymer Chemistry (2015), 6(18), 3372-3381. 

·        Arslan, M.; Gevrek, T. N.; Sanyal, R.; Sanyal, A. “Fabrication of poly(ethylene glycol)​-​based cyclodextrin containing hydrogels via thiol-​ene click reaction European Polymer Journal (2015), 62, 426-434.  

·        Arslan, M.; Gevrek, T. N.; Sanyal, A.; Sanyal, R. “Cyclodextrin mediated polymer coupling via thiol-​maleimide conjugation: facile access to functionalizable hydrogels” RSC Advances (2014),  4, 57834–57841.

·        Park, E. J.; Gevrek, T. N.; Sanyal, R.; Sanyal, A. “Indispensable Platforms for Bioimmobilization: Maleimide-​Based Thiol Reactive Hydrogels” Bioconjugate Chemistry (2014), 25(11) 2004-2011.

·        Arslan, M.; Gevrek, T. N.; Lyskawa, J.; Szunerits, S.; Boukherroub, R.; Sanyal, R.; Woisel, P.; Sanyal, A. “Bioinspired Anchorable Thiol-​Reactive Polymers: Synthesis and Applications Toward Surface Functionalization of Magnetic Nanoparticles” Macromolecules (2014), 47(15), 5124-5134.

·        Arslan, M.; Gok, O.; Sanyal, R.; Sanyal, A. “Clickable Poly(ethylene glycol)​-​Based Copolymers Using Azide-​Alkyne Click Cycloaddition-​Mediated Step-​Growth Polymerization” Macromolecular Chemistry and Physics (2014), 215(22), 2237-2247. 

·        Beria, L.; Gevrek, T. N.; Erdog, A.; Sanyal, R.; Pasini, D.; Sanyal, A. “'Clickable' hydrogels for all: facile fabrication and functionalization” Biomaterials Science (2014), 2(1), 67-75.

·        Gok, O.; Yigit, S.; Kose, M. M.; Sanyal, R.; Sanyal, A. “Dendron-polymer conjugates via the diels-alder "click" reaction of novel anthracene-based dendrons” Journal of Polymer Science: Polymer Chemistry (2013), 51(15), 3191-3201.

·        Onbulak, S.; Tempelaar, S.; Pounder, R. J.; Gok, O.; Sanyal, R.; Dove, A. P.; Sanyal, A. “Synthesis and Functionalization of Thiol-Reactive Biodegradable Polymers” Macromolecules (2012), 45, 1715-1722.

·        Acikgoz, S.; Sarpkaya, I.; Milas, P.; Inci, M. N.; Demirci, G.; Sanyal, R. “Investigation of Fluorescence Dynamics of BODIPY Embedded in Porous Silicon and Monitoring Formation of a SiO2 Layer via a Confocal FLIM-Based NSET Method” Journal of Physical Chemistry C (2011), 115, 22186-22190.

·        Yiğit, S.; Sanyal, R.; Sanyal, A. “Fabrication and Functionalization of Hydrogels through ‘Click’ Chemistry” Chemistry an Asian Journal (2011), 10, 2648-2659.

·        Cengiz, N.; Kabadayioglu, H.; Sanyal, R. “Orthogonally Functionalizable Copolymers Based on a Novel Reactive Carbonate Monomer” Journal of Polymer Science Part A: Polymer Chemistry (2010), 48, 4737- 4746.

·        Altin, H.; Kosif, I.; Sanyal, R. “Fabrication of “Clickable” Hydrogels via Dendron-Polymer Conjugates” Macromolecules (2010), 43, 3801-3808.

·        Kosif, I.; Sanyal, R.; Sanyal, A. “Fabrication of Maleimide Containing Thiol Reactive Hydrogels via Diels-Alder/retro Diels-Alder Strategy” Macromolecules (2010) 43, 4140 - 4148.

·        Dispinar, T.; Sanyal, R.; Sanyal A. "A Diels-Alder/Retro Diels-Alder Strategy to Synthesize Polymers Bearing Maleimide Side Chains." Journal of Polymer Science Part A: Polymer Chemistry (2007), 45 (20), 4545 – 4551. COVER ARTICLE.

·        Nomak, R.; Snyder, J. K. “Inverse Electron Demand Diels-Alder Chemistry in the Synthesis of a Regioselectively Protected Analogue of the Staurosporine Aglycone.” Tetrahedron Letters (2001), 42, 7929 - 7933.

·        Girardot, M.; Nomak, R.; Snyder, J. K. “Direct Conversion of Heteroaromatic Esters to Methyl Ketones with Trimethylaluminum: Nonsymmetrically Disubstituted 1,2,4,5-Tetrazines.” Journal of Organic Chemistry (1998), 63, 10063 - 10068.

·        Daly, K.; Nomak, R.; Snyder, J. K. “A Facile Preparation of Pyrrolo[3,4-b]indoles.” Tetrahedron Letters (1997), 38, 8611 - 8614.

 

Patents:

1.     Yuan, C. C.; Yang, K.; Vanderplas, S.; Riahi, B.; Potashman, M.; Patel, V. F.; Nomak, R.; Li, A.; Huang, Q.; Harmange, J.-C.; Askew, B. C., Jr. "Substituted arylamine derivatives and methods of use" U.S. Pat. Appl. Publ. (2009), US 2009143355 A1.

2.     Groneberg, R. D.; Askew, B. C., Jr.; D'Amico, D.; Zhan, J.; Toro, A.; Kim, Y.; Mareska, D. A.; Han, N.; Fotsch, C. H.; Liu, Q.; Riahi, B.; Yang, K.; Li, A.; Yuan, C. C.; Biswas, K.; Harried, S.; Nguyen, T.; Qian, W.; Chen, J.J.; Nomak, R. “Compounds and methods of use.” U.S. Pat. Appl. Publ. (2009), US 2009048224 A1.

3.     Chen, J.J.; Askew, B.; Biswas, K.; Chau, J.N.; D'Amico, D. C.; Harried, S.; Nguyen, T.; Qian, W.; Zhu, J.; Fotsch, C. H.; Li, A.; Liu, Q.; Nishimura, N.; Peterkin, T.; Riahi, B.; Yuan, C. C.; Han, N.; Nomak, R.; Yang, K. “Piperazine derivatives and methods of use.” U.S. Pat. Appl. Publ. (2009), US 200905446 A1.

4.     Germain, J.; Askew, B. C., Jr.; Bauer, D.; Choquette, D.; Dipietro, L. V.; Graceffa, R.; Harmanage, J.-C.; Huang, Q.; Kim, J. L.; La, D.; Li, A.; Nishimura, N.; Nomak, R.; Patel, V.; Potashman, M.; Riahi, B.; Storz, T.; Van der Plas, S.; Yang, K.; Yuan, C. C. “Aminopyridinecarboxamide compounds and their preparation, pharmaceutical compositions and use in the treatment of angiogenesis mediated diseases.” PCT Int. Appl. (2007), WO 2007048070 A2

5.     Germain, J.; Askew, B. C., Jr.; Bauer, D.; Choquette, D.; Dipietro, L. V.; Graceffa, R.; Harmanage, J.-C.; Huang, Q.; Kim, J. L.; La, D.; Li, A.; Nishimura, N.; Nomak, R.; Patel, V.; Potashman, M.; Riahi, B.; Storz, T.; Van der Plas, S.; Yang, K.; Yuan, C. C. “Compounds and methods of use.” U.S. Pat. Appl. Publ.  (2007), US 2007185171 A1.

6.     Askew, B. C.; Aya, T.; Biswas, K.; Cai, G.; Chen, J. J.; Han, N.; Liu, Q.; Nguyen, T.; Nishimura, N.; Nomak, R.; Peterkin, T.; Qian, W.; Yang, K.; Yuan, C. C.; Zhu, J.; D' Amico, D. C.; Human, J. B.; Huang, Q. "Preparation of 1,2,3,4-tetrahydropyrazin-2-yl acetamides as bradykinin B1 receptor antagonists for treating pain and diseases such as inflammation-mediated diseases." U.S. Pat. Appl. Publ. (2006), US 2006025400 A1.

7.     Yuan, C. C.; Yang, K.; Vanderplas, S.; Riahi, B.; Potashman, M.; Patel, V. F.; Nomak, R.; Li, A.; Huang, Q.; Harmange, J.-C.; Askew, B. C., Jr. "Preparation of substituted arylamine derivatives, particularly 2-aminonicotinamides, as antitumor agents." PCT Int. Appl. (2006), WO 2006012374 A1.

8.     Tegley, C.; Adams, J. A.; Askew, B. C., Jr.; Croghan, M.; Elbaum, D.; Germain, J.; Habgood, G. J.; Harried, S.; Li, A.; Nishimura, N.; Nomak, R.; Tasker, A.; Yang, K.  “Preparation of substituted 2,3-dihydro-1H-isoindol-1-one derivatives as VEGF modulators and methods of use against cancer and other disorders.” PCT Int. Appl.  (2005), WO 2005021532 A1.

9.     Tegley, C.; Adams, J. A.; Askew, B.; Croghan, M.; Elbaum, D.; Germain, J.; Habgood, G. J.; Harried, S.; Li, A.; Nishimura, N.; Nomak, R.; Tasker, A.; Yang, K. “Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use” U.S. Pat. Appl. Publ. (2005), US 2005054670 A1.

10.  Groneberg, R. D.; Zhan, J.; Askew, B. C. Jr; D'Amico, D. C.; Han, N.; Fotsch, C. H.; Liu, Q.; Riahi, B.; Zhu, J.; Yang, K.; Chen, J. J.; Nomak, R. “Preparation of cyclic amine derivatives as bradykinin antagonists and their use in the treatment of pain and inflammation” U.S. Pat. Appl. Publ. (2005), US 2005234044 A1 

11.  Chen, J.J.; Askew, B.; Biswas, K.; Chau, J.N.; D'Amico, D. C.; Harried, S.; Nguyen, T.; Qian, W.; Zhu, J.; Fotsch, C. H.; Li, A.; Liu, Q.; Nishimura, N.; Peterkin, T.; Riahi, B.; Yuan, C. C.; Han, N.; Nomak, R.; Yang, K. “Preparation of arylsufonyloxo-piperazinylacetamides for treatment of inflammation and pain.” U.S. Pat. Appl. Publ. (2005), US 2005014749 A1.

12.  Askew, B.C.; Adams, J.; Booker, S.; Chen, G.; Dipietro, L. V.; Elbaum, D.; Germain, J.; Geuns-Meyer, S. D.; Habgood, G. J.; Handley, M.; Huang, Q.; Kim, T.; Li, A.; Nishimura, N.; Nomak, R.; Patel, V. F.; Riahi, B.; Kim, J. L.; Xi, N.; Yang, K.; Yuan, C. C. “Substituted alkylamine derivatives and methods of use”  U.S. Pat. Appl. Publ. (2005), US 2005261313 A1. US 6995162 B2.

13.  Groneberg, R. D.; Zhan, J.; Askew, B.; D'Amico, D.; Han, N.; Fotsch, C. H.; Liu, Q.; Riahi, B.; Zhu, J. Yang, K. Chen, J.J.; Nomak, R. “Preparation of cyclic amine derivatives as bradykinin antagonists and their use in the treatment of pain and inflammation.” PCT Int. Appl. (2004), WO 2004092164 A1.

14.  Askew, B.C.; Adams, J.; Booker, S.; Chen, G.; Dipietro, L. V.; Elbaum, D.; Germain, J.; Geuns-Meyer, S. D.; Habgood, G. J.; Handley, M.; Huang, Q.; Kim, T.; Li, A.; Nishimura, N.; Nomak, R.; Patel, V. F.; Riahi, B.; Kim, J. L.; Xi, N.; Yang, K.; Yuan, C. C. “Substituted 2-alkylamine nicotinic amide derivatives and use there of” PCT Int. Appl. (2004), WO 2004007458 A1.

15.  Patel, V. F.; Askew, B.C.; Booker, S.; Chen, G.; Dipietro, L. V.; Germain, J.; Habgood, G. J.; Huang, Q.; Kim, T.; Nishimura, N.; Nomak, R.; Riahi, B.; Yuan, C. C.; Elbaum, D.; Li, A. “Substituted amine derivatives and methods of use in the treatment of angiogenesis related disorders” PCT Int. Appl. (2004), WO 2004007481 A2. US7102009 B2.

16.  Groneberg, R. D.; Askew, B.; D'Amico, D.; Zhan, J.; Toro, A.; Suzuki, H.; Mareska, D. A.; Han, N.; Fotsch, C. H.; Liu, Q.; Riahi, B.; Yang, K.; Li, A.; Yuan, C.; Biswas, K.; Harried, S.; Nguyen, T.; Qian, W.; Chen, J. J.; Nomak, R. “Preparation of N-bicyclyl-3-[[(hetero)arylsulfonyl]amino]-3-(hetero)aryl-propionamides as bradykinin receptor modulators for treatment of pain, inflammation, and other conditions.” PCT Int. Appl. (2004), WO 2004092116 A1.

17.  Askew, B. C.; De Morin, F. F.; Hague, A.; Laber, E.; Li, A.; Liu, G.; Lopez, P.; Nomak, R.; Santora, V.; Tegley, C.; Yang, K.  “Preparation of N-thiazolyl-N'-pyridyl ureas as antitumor agents.” U.S. Pat. Appl. Publ. (2004), US 20040039029 A1.

18.  Askew, B. C.; De Morin, F. F.; Hague, A.; Laber, E.; Li, A.; Liu, G.; Lopez, P.; Nomak, R.; Santora, V.; Tegley, C.; Yang, K.  “Thiazolyl urea compounds and methods of uses” U.S. Pat. Appl. Publ. (2004), US 2004044044 A1. US 6645990 B2.

19.  Santora, V.; Askew, B. C.; De Morin, F. F.; Hague, A.; Laber, E.; Li, A.; Liu, G.; Lopez, P.; Nomak, R.; Tegley, C.; Yang, K. “Thiazolyl urea compounds for the treatment of cancer” PCT Int. Appl. (2003), WO 2003070727 A1.

20.  Patel, V. F.; Askew, B.; Booker, S.; Chen, G.; Dipietro, L. V.; Germain, J.; Habgood, G. J.; Huang, Q.; Kim, T.; Li, A.; Nishimura, N.; Nomak, R.; Riahi, B.; Yuan, C. C.; Elbaum, D. “Preparation of amino heteroaryl amides for use in pharmaceutical compositions for the treatment of angiogenesis mediated diseases such as cancer.” U.S. Pat. Appl. Publ. (2003) US 2003203922 A1. US7102009 B2.

21.  Askew, B.C.; Adams, J.; Booker, S.; Chen, G.; Dipietro, L. V.; Elbaum, D.; Germain, J.; Geuns-Meyer, S. D.; Habgood, G. J.; Handley, M.; Huang, Q.; Kim, T.; Li, A.; Nishimura, N.; Nomak, R.; Patel, V. F.; Riahi, B.; Kim, J. L.; Xi, N.; Yang, K.; Yuan, C. C. “Preparation of 2-aminopyridine-3-carboxamides as remedies for angiogenesis mediated diseases.” U.S. Pat. Appl. Publ. (2003), US 2003225106 A1.

22.  Askew, B. C.; De Morin, F. F.; Hague, A.; Laber, E.; Li, A.; Liu, G.; Lopez, P.; Nomak, R.; Santora, V.; Tegley, C.; Yang, K. “Preparation of N-thiazolyl-N'-pyridyl ureas as antitumor agents.” U.S. Pat. Appl. Publ. (2002), US 2002193405 A1.